The Scientific Literature Supporting EdoxA�

smiling-coupleIn numerous scientific publications describing clinical studies conducted in both the United States and Europe, the combination of PycnogenolA� and L-Arginine has demonstrated efficacy in increasing and enhancing sexual pleasure and performance. A testament to the unassailable scientific evidence supporting the effectiveness of EdoxA� is that the combination of PycnogenolA� and l-Arginine has been granted a patent (US6,565,851 B2) for the relief of the symptoms of ED. Several of these studies are summarized below.

Treatment of Erectile Dysfunction with PycnogenolA� and L-Arginine
Stanislavov R. et al. Journal of Sex and Marital Therapy, 29(3) 207-213, 2003

beach-couple40 men (aged 25-45 years) with erectile dysfunction of at least 3 months duration were studied. Initially these men where treated with L-Arginine alone for one month, and a poor response was achieved whereby only 5% of the men experienced normal erectile function. However, when PycnogenolA� was added to the regiment, a significant improvement was noted. After one month of 80 mg of PycnogenolA�/day, 80% of the men reported normal erections. This response improved in a dose dependant fashion whereby increasing the PycnogenolA� dose to 120 mg per day, 92.5% of the men experienced a return of normal erectile function. Furthermore, the study demonstrated that as one increased the dose of PycnogenolA�, the time to achieve an erection decreased and the duration of the erection increased. At a dose of 120 mg of PycnogenolA�, the duration of the erection increased to 15 A� 3 minutes. No adverse side effects were reported by the men taking PycnogenolA� and L-Arginine. The study concluded that a�?Supplementation with arginine and PycnogenolA� on a regular basis renders individuals with ED to be healthy lovers with a satisfying sexualitya�?

Prelox For Improvement of Erectile Function: A Review
Lamm S. et al. European Bulletin of Drug Research 11 (3), 29-37, 2003

In a United States study performed by Dr. Steven Lamm, 37 men with erectile dysfunction who where prospectively given therapy with L-Arginine and PycnogenolA� were analyzed. 81% of the men reported that treatment with L-Arginine and PycnogenolA� had improved their ability to engage in sexual activity. An increased IIEF score was reported in 70% of the men with a 10% mean IIEF score increase for the study group as a whole. 73% of the men reported that L-Arginine and PycnogenolA� made it easier to initiate an erection and 70% stated that it made it easier to sustain an erection. A sub analysis of the study population revealed that L-Arginine and PycnogenolA� demonstrated increased efficacy particularly in men who at baseline suffered from moderate and mild erectile dysfunction. In the subgroup of men having the mildest forms of erectile dysfunction, complete restoration of their sexual function was observed. No adverse side effects were reported by the men taking PycnogenolA� and L-Arginine. The authors concluded that L-Arginine and PycnogenolA� a�?is effective for preserving healthy sexual function in aging men experiencing first signs of lowered erectile performance.a�?

Improvement of Erectile Function with Prelox: A Randomized Double-Blind, Placebo Controlled, Crossover Trial
Stanislavov R. et al. International Journal of Impotence Research Mar-Apr; 20(2) 173-80, 2008

couple-enjoy-on-beach50 men (aged 30-50 years) with ED were treated in a prospective double blind fashion for one month either with placebo or a combination of L-Arginine and 80 mg of PycnogenolA�. At the conclusion of the initial treatment month, the two groups were crossed over whereby the original placebo group then received L-Arginine and 80 mg of PycnogenolA�, and the initially treated group then received placebo for an additional month. At the conclusion of the treatment period, men treated with L-Arginine and PycnogenolA� achieved normal erectile function (normal defined as an IIEF score of > 25). The treated men reported improved IIEF scores from 11-17 to 26-30. Those treated with placebo did not demonstrate a significant improvement in erectile function. On average it took approximately 5 days for the combination of L-Arginine and PycnogenolA� to improve erectile performance. The mean number of intercourse events more than doubled while on study drug. In the specific IIEF domains of orgasmic function, sexual desire, and intercourse satisfaction, significant improvement was reported. The study also noted that the improvement in erectile function following L-Arginine and PycnogenolA� intake extended beyond the treatment period, suggesting a sustained effect. Furthermore, in this study total testosterone levels also significantly improved in the group of men taking L-Arginine and PycnogenolA�. No adverse side effects were reported by the men taking PycnogenolA� and L-Arginine. The authors concluded that treatment with L-Arginine and PycnogenolA� a�?seems to offer a safe and very effective alternative to existing medicationsa�? for the treatment of erectile dysfunction.

Endothelium a��Dependant Vascular effects of PycnogenolA�.
Fitzpatrick D.F et al. Journal of Cardiovascular Pharmacology 32, 509-515, 1998

PycnogenolA� is a very powerful antioxidant that has been shown to stimulate nitric oxide synthesis. Nitric oxide is the key biological compound responsible for penile smooth muscle relaxation and vasodilatation resulting in erectile function.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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